Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit

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Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit.

BACKGROUND Erythropoietin (EPO) may improve cardiac function and induce neovascularisation in experimental models of chronic heart failure (CHF). However, the increased haematocrit associated with EPO treatment might exert concomitant deleterious effects. AIM To investigate the haematocrit independent effects of EPO on cardiac function. METHODS AND RESULTS Rats underwent permanent coronary ...

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ژورنال

عنوان ژورنال: European Journal of Heart Failure

سال: 2008

ISSN: 1388-9842

DOI: 10.1016/j.ejheart.2007.10.008